 a review was conducted from may 2018 december 2022 for transfusion transmitted sepsis cases in the u s attributable to polymicrobial contaminated apheresis platelet components including acinetobacter calcoaceticus baumannii complex or staphylococcus saprophyticus isolated from patients and components seven sepsis cases from 6 platelet donations from 6 different donors were identified in patients from 6 states 3 patients died whole genome sequencing showed environmental isolates from the manufacturer were closely related genetically to patient and platelet isolates indicating the manufacturer was the most probably source of recurrent polymicrobial contamination 